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Some (but not nearly all) things worth considering:
The history of how chain stores came about and how their existence has impacted local mom-and-pop stores as they’ve grown and multiplied
The impact such stores have on local businesses (if massive retail stores can drastically mark down the price of an item because of a massive national gross budget how can an independent store try and compete)
Do they provide a bump in available jobs? If they force local stores to close do they trigger a loss in jobs?
What happens if one of the big stores closes? Who’s left to fill the void?
Is the accessibility and availability of cheaper goods beneficial to households on the lower end of the economic spectrum?